Description

Better understanding alveolarization mechanisms could help improving prevention and treatment of diseases characterized by reduced alveolar number, especially bronchopulmonary dysplasia (BPD). Although signaling through fibroblast growth factor (FGF) receptors is essential for alveolarization, involved ligands are unidentified. FGF18 whose expression peaks during alveolar septation is likely to be involved. Herein, a mouse model of inducible, lung-targeted FGF18-transgene was used to advance the onset of FGF18 expression, and genome-wide expression changes were determined.

Publication Title

Profiling target genes of FGF18 in the postnatal mouse lung: possible relevance for alveolar development.

Alternate Accession IDs

E-GEOD-22283

Sample Metadata Fields

Specimen part, Disease