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accession-icon GSE18926
Expression data from the liver of wild-type and Cnot3+/- mice
  • organism-icon Mus musculus
  • sample-icon 10 Downloadable Samples
  • Technology Badge Icon

Description

This SuperSeries is composed of the SubSeries listed below.

Publication Title

Obesity resistance and increased hepatic expression of catabolism-related mRNAs in Cnot3+/- mice.

Alternate Accession IDs

E-GEOD-18926

Sample Metadata Fields

Sex, Specimen part

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accession-icon GSE18925
Expression data from the liver of wild-type and Cnot3+/- mice: Fed vs Fasted
  • organism-icon Mus musculus
  • sample-icon 6 Downloadable Samples
  • Technology Badge Icon

Description

Decay of mRNAs initiates with shortening of the poly(A) tail. Although the CCR4-NOT complex participates in deadenylation, how it becomes activates remain obscure. We show that complete deficiency in CNOT3, subunit 3 of this complex, is lethal in mice, but that heterozygotes survive as lean mice with hepatic and adipose tissues containing reduced lipid levels. Cnot3+/- mice have enhanced metabolic rates and remain lean on high-fat diets. We further provide evidence suggesting that CNOT3, by changing its level in response to feeding conditions, affects the activity of the CCR4-NOT deadenylase against poly(A) tails of specific mRNAs coding for proteins involved in metabolism of carbohydrates and fats.

Publication Title

Obesity resistance and increased hepatic expression of catabolism-related mRNAs in Cnot3+/- mice.

Alternate Accession IDs

E-GEOD-18925

Sample Metadata Fields

Sex, Specimen part

View Samples
accession-icon GSE18924
Expression data from the liver of wild-type and Cnot3+/- mice: Fasted
  • organism-icon Mus musculus
  • sample-icon 4 Downloadable Samples
  • Technology Badge Icon

Description

Decay of mRNAs initiates with shortening of the poly(A) tail. Although the CCR4-NOT complex participates in deadenylation, how it becomes activates remain obscure. We show that complete deficiency in CNOT3, subunit 3 of this complex, is lethal in mice, but that heterozygotes survive as lean mice with hepatic and adipose tissues containing reduced lipid levels. Cnot3+/- mice have enhanced metabolic rates and remain lean on high-fat diets.

Publication Title

Obesity resistance and increased hepatic expression of catabolism-related mRNAs in Cnot3+/- mice.

Alternate Accession IDs

E-GEOD-18924

Sample Metadata Fields

Sex, Specimen part

View Samples
accession-icon GSE48622
Transcriptional Profiling of Neuronal APP/APLP2 Double-Conditional Knockout Mice.
  • organism-icon Mus musculus
  • sample-icon 16 Downloadable Samples
  • Technology Badge Icon

Description

Gene expression analysis of 2-month-old APP/APLP2 double-conditional Knockout (N-dCKO) mice and littermate APLP2 knockout controls, APP knockout and wildtype controls.

Publication Title

Soluble amyloid precursor protein (APP) regulates transthyretin and Klotho gene expression without rescuing the essential function of APP.

Alternate Accession IDs

E-GEOD-48622

Sample Metadata Fields

Sex, Age, Specimen part

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accession-icon GSE37382
Subgroup specific somatic copy number aberrations in the medulloblastoma genome [mRNA]
  • organism-icon Homo sapiens
  • sample-icon 285 Downloadable Samples
  • Technology Badge Icon Affymetrix Human Gene 1.1 ST Array (hugene11st)

Description

Affymetrix Human Gene 1.1 ST Array profiling of 285 primary medulloblastoma samples.

Publication Title

Subgroup-specific structural variation across 1,000 medulloblastoma genomes.

Alternate Accession IDs

E-GEOD-37382

Sample Metadata Fields

Sex, Age

View Samples
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