submitter_institution:UNC-Chapel Hill Results

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Organism

Mus musculus (125)

Technology

Microarray (125)

Platform

Affymetrix Mouse Genome 430 2.0 Array (mouse4302) (125)

Includes Publication

GSE6632

Hepatocellular carcinoma follows loss of liver-gender specificity in mice

Mus musculus
6 Downloadable Samples

Description

We are investigating hepatic transcriptional responses associated with castration and tumorigenic hepatitis induced by Helicobacter hepaticus infection in mature male A/JCr mice

Publication Title

Hepatocellular carcinoma associated with liver-gender disruption in male mice.

Alternate Accession IDs

E-GEOD-6632

Sample Metadata Fields

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GSE9097

H. hepaticus infection and liver cancer

Mus musculus
4 Downloadable Samples

Description

We are investigating the transcriptional response of mice infected with Helicobacter hepaticus and links to liver cancer

Publication Title

Genetic susceptibility to chronic hepatitis is inherited codominantly in Helicobacter hepaticus-infected AB6F1 and B6AF1 hybrid male mice, and progression to hepatocellular carcinoma is linked to hepatic expression of lipogenic genes and immune function-associated networks.

Alternate Accession IDs

E-GEOD-9097

Sample Metadata Fields

No sample metadata fields

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GSE5198

Transcriptional profiling of mouse ileum in response to colonization with a zebrafish or mouse gut microbiota

Mus musculus
18 Downloadable Samples

Description

We compared gene expression in the small intestine (ileum) of mice that were either (i) germ-free, (ii) colonized with a conventional mouse cecal microbiota, (iii) colonized with a conventional zebrafish gut microbiota, or (iv) colonized with Pseudomonas aeruginosa PAO1.

Publication Title

Reciprocal gut microbiota transplants from zebrafish and mice to germ-free recipients reveal host habitat selection.

Alternate Accession IDs

E-GEOD-5198

Sample Metadata Fields

Specimen part

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GSE28644

Gene Expression Data Following Chronic Vehicle or Fluoxetine Treatment in Thirty Mouse Inbred Lines

Mus musculus
57 Downloadable Samples

Description

In order to understand how biochemical and genetic differences correlate with treatment response, we measured depressive-like behavior, gene expression and the levels of thirty-six neurobiochemical analytes across a panel of genetically-diverse mouse inbred lines after chronic treatment with vehicle or fluoxetine. Neurobiochemical markers were chosen based on their putative molecular function within pathways proposed to underlie depression, which include neuronal transmission, HPA-axis regulation, and neuroimmune processes. The goal of this study is to establish genetic and biochemical biomarkers that can predict treatment response and to propose a molecular pathway that is critical in mediating anti-depressant response.